New viruses and old drugs: searching for treatments for COVID-19

By: Sandra Porter (@digitalbio)
Tue Feb 18, 2020
Novel Coronavirus SARS-CoV-2
This transmission electron microscope image shows 2019-nCoV, the virus that causes COVID-19, isolated from a patient in the U.S., and emerging from the surface of cells cultured in the lab.
Credit: NIAID-RML

Note:  the official name for the disease is COVID-19.  The virus that causes the disease is known as nCoV, and 2019-nCoV, and sometimes SARS-CoV-2.  

Resources for teaching:

1.  Coronavirus images from NIAID-RML, from the Public Health Image Library

2.  A map showing how the virus spread Healthmap.org/covid-19  and another map from Johns Hopkins University

Global spread of the novel coronavirus

3.  Another map - with case counts by state (US) or province (Canada) from the Humanistic GIS Lab at the University of Washington.

This map shows the number of infections in each state.

4.  Current information on the outbreak:  CDC Coronavirus Disease 2019

5.  What is it like to have COVID-19?  What effects does it have on your body?  National Geographic:  Here's what coronavirus does to the body

6.  SARS-CoV-2 life cycle from ViralZone

Beta coronavirus life cycle

7.  The annotated Novel Coronavirus proteome from ViralZone

8.  SARS-CoV-2 DNA and RNA sequences at the NCBI

9.  nCoV phylogeny vs geography

Global spread and change in novel coronavirus genomes from Nextstrain.org

10.  Structures of antibodies bound to SARS or MERS proteins.

11.  Companies working on COVID-19 tests, vaccines, treatments.

12.  Spread sheet for NCoV -19 proteins

 

Articles:

Galasiti Kankanamalage AC, Kim Y, Damalanka VC, et al. Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design elementEur J Med Chem. 2018;150:334–346. doi:10.1016/j.ejmech.2018.03.004

Kim Y, Liu H, Galasiti Kankanamalage AC, et al. Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor [published correction appears in PLoS Pathog. 2016 May;12(5):e1005650]. PLoS Pathog. 2016;12(3):e1005531. Published 2016 Mar 30. doi:10.1371/journal.ppat.1005531

Takano T, Akiyama M, Doki T, Hohdatsu T. Antiviral activity of itraconazole against type I feline coronavirus infectionVet Res. 2019;50(1):5. Published 2019 Jan 18. doi:10.1186/s13567-019-0625-3

 

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